And make sure you talk to your doctor before you get any vaccinations.These medicines may increase your risk of getting cancer, including lymphoma.The full terms of this license are available at https:// incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
Medicine is one of the many tools your doctor has to treat a health problem.
Accepted for publication 17 December 2016 Published 13 January 2017 Volume 20 Pages 211—223 DOI https://doi.org/10.2147/DDDT.
S104233 Checked for plagiarism Yes Review by Single-blind Peer reviewers approved by Dr Junhua Mai Peer reviewer comments 3 Editor who approved publication: Dr Georgios Panos Department of Rheumatology, Gaetano Pini Institute, Milan, Italy Abstract: The introduction of biological therapies into clinical practice has dramatically modified the natural history of chronic inflammatory diseases, such as rheumatoid arthritis (RA).
In the last few decades, the scientific knowledge on RA pathogenesis vastly improved, leading to the identification of new proinflammatory molecules as potential therapeutic targets.
Several in vitro and in vivo studies showed that granulocyte-macrophage colony-stimulating factor (GM-CSF), known to be a hematopoietic factor, is also one of the proinflammatory cytokines involved in macrophage activation, crucial for the pathogenic network of RA.